Modeling and simulating study on disorder of associative memory function of hippocampal CA3 region caused by synaptic deletion based on Hopfield-like spiking neural network model
10.3760/cma.j.issn.1673-4181.2010.04.003
- VernacularTitle:基于类Hopfield脉冲神经网络模型由突触缺失导致海马CA3区联想记忆功能障碍的建模仿真研究
- Author:
Wangxiong ZHAO
;
Qingli QIAO
;
Dan WANG
- Publication Type:Journal Article
- Keywords:
Hippocampal CA3;
Synaptic deletion;
Hopfield-like neural network;
Autoassociative memory;
Heteroassociative memory
- From:
International Journal of Biomedical Engineering
2010;33(4):201-204,211
- CountryChina
- Language:Chinese
-
Abstract:
Objective A spiking Hopfield-like neural network was proposed and used to simulate the disorder of hippocampal associative memory disorder caused by synaptic deletion.Methods A three-layered Hopfield-like spiking neural network model with auto-associative memory function and hetero-associative memory function was proposed according to anatomical structure of hippocampal CA3,and both associative memories of the models were simulated under Matlab platform.Disorder of hippocampal associative memory was also simulated according to Ruppin's 'synaptic deletion' theory.Results With the increasing of synaptic deletion level,both associative memory functions impaired gradually.Conclusion Synaptic deletion of hippocampal CA3 region can lead to the disorder of autoassociative memory as well as heteroassociative memory.
