Correlation between plasma levels of urotensin Ⅱ and severity of liver fibrosis in CCl4 rats
10.3760/cma.j.issn.1673-4203.2010.10.008
- VernacularTitle:血浆尾加压素Ⅱ水平与CCL4大鼠肝纤维化程度的关系
- Author:
Xuemei MA
;
Diangang LIU
;
Zhigang BAI
- Publication Type:Journal Article
- Keywords:
Urotensin Ⅱ;
Liver fibrosis
- From:
International Journal of Surgery
2010;37(10):667-670,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the correlation between urotensin Ⅱ (UⅡ) concentration and the severity of liver fibrosis. Methods Liver fibrosis model was induced in rats by intraperitoneal administration of CCl4. At 4,6,8 weeks, the rats were sacrificed, and the hepatic tissue hydroxyproline (HYP) content was measured. Hepatic tissue specimens were histopathologically evaluated according to a fibrosis scoring system. Plasma UⅡ levels were measured by ELISA method. Results Plasma UⅡ gradually increased with the increase of duration of CCL4, UⅡ concentration correlated to liver fibrosis ( R2 = 0.875, P ＜ 0.05) and hepatic HYP( R2 = 0.65, P ＜0.05). Conclusion UⅡ was involved in the pathogenesis of liver fibrosis.
