Progress in calcification and anticalcification research on tissue cardiac valve substitutes
10.3760/cma.j.issn.1673-4181.2010.05.011
- VernacularTitle:心脏瓣膜修复材料钙化和抗钙化研究进展
- Author:
Bing SONG
;
Debin LIU
;
Baishun GAO
- Publication Type:Journal Article
- Keywords:
Biomaterial;
Cardiac valve;
Calcification;
Anticalcification
- From:
International Journal of Biomedical Engineering
2010;33(5):301-304,316
- CountryChina
- Language:Chinese
-
Abstract:
Calcification is a major cause of clinical failure of bioprosthetic and other tissue cardiac valve substitutes.The mechanism of calcification of cardiac valve substitutes is quite complex and has a variety of determinants,involving reaction of calcium-containing extracellular fluid with membrane-associated phosphorus to yield calcium phosphate mineral deposits.The most promising anticalcification strategies have included binding of calcification inhibitors to glutaraldehyde fixed tissue,removal or modification of calcifiable components,modification of glutaraldehyde fixation and use of tissue cross linking agents other than glutaraldehyde.This article reviews current progress toward the research of calcification and anticalcification strategies that are under investigation either in advanced animal models or in clinical trials.
