Progress of TNF-α and TNF-α blockade treatment in asthma
10.3760/cma.j.issn.1673-4408.2010.06.015
- VernacularTitle:肿瘤坏死因子-α与哮喘及其拮抗剂治疗研究进展
- Author:
Zhongqiang LI
- Publication Type:Journal Article
- Keywords:
Asthma;
Tumor necrosis factor-α;
Etanercept
- From:
International Journal of Pediatrics
2010;37(6):594-596,600
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic inflammatory disease of the airways, pathogenesis is complex, variety of inflammatory cells and cytokines involved in the airway allergic diseases. Tumor necrosis factor-alpha(TNF-α)plays a role in the pathogenesis of asthma as an integral part of inflammatory mediators. Suffering from asthma,respiratory epithelial cells, vascular endothelial cells may release TNF-α which may cause airway hyperreactivity and the partial inflammation, and play a role in airway remodeling. The studies show that anti-TNF-α therapy has certain therapeutic action to airway remodeling in asthma patient and severe asthma, it can decline the level of TNF-α in the blood and the respiratory, reduce airway inflammation, provide new ideas and methods for the treatment of asthma.
