Progress in the relationship between P-glycoprotein and refractory epilepsy
10.3760/cma.j.issn.1673-4408.2010.06.023
- VernacularTitle:P-糖蛋白与难治性癫(癎)的相关性研究进展
- Author:
Shujing XU
- Publication Type:Journal Article
- Keywords:
P-glycoprotein;
Refractory epilepsy
- From:
International Journal of Pediatrics
2010;37(6):620-621,624
- CountryChina
- Language:Chinese
-
Abstract:
The research of epilepsy drug-resistant mechanism has been paid more and more attention. Pglycoprotein(Pgp) ,being one of the hot points of recent research,plays the transporting role in the body,and its coding genetic polymorphism also affects its expression. The relationship between Pgp and drug-resistant epilepsy is reviewed based on the coding genetic polymorphisms, multidrug transporters hypothesis, concentration equilibrium transport assay, and Pgp inhibition effect.
