Progress of laboratory diagnosis of acute pancreatitis in children
10.3760/cma.j.issn.1673-4408.2010.05.020
- VernacularTitle:小儿急性胰腺炎的实验室诊断研究进展
- Author:
Xiaohong XU
- Publication Type:Journal Article
- Keywords:
Acute pancreastitis,children;
Laboratory diagnosis
- From:
International Journal of Pediatrics
2010;37(5):503-505,508
- CountryChina
- Language:Chinese
-
Abstract:
The traditional laboratory markers of acute pancreatitis in children include serum amylase and urine amylase, serum lipase, urinary trypsinogen-2, C-reactive protein, cytokines, amylase and creatinine clearance ratio and so on. They can be simply detected and economic, but the sensitivity and specificity are not satisfied. Several new laboratory markers of acute pancreatitis in children, which include procalcitonin, phospholipase A2, PankrinTM, trypsinogen activation peptide, carboxypeptidase B activation peptide, human pancreas-specific protein/procarboxypeptidase B, polymorphonuclear elastase, serum amyloid protein A, and as well as intercellular adhesion molecule- 1, have been found and applied in recent years .They can provide reliable judgment methods for early diagnosis and prediction of the severity of acute pancreatitis in children, but most of the new laboratory markers are rarely used in clinic because they are difficult to be detected and expensive. More sensitive, specific, cheap and operable laboratory markers which can be used in clinic are to be explored.
