Expression of COX-2, E-ca and VEGF-c in colorectal cancer and its significance

VernacularTitle:COX-2、E-ca和VEGF-c在大肠癌中的表达及意义
Author: Min XIE ; Kai TAN ; Heshun XIA ; Changming WU
Publication Type:Journal Article
Keywords: Colorectal cancer; Cyclooxygenase-2; Epithelial cadherin; Vascular endothelial growth factor-c
From: International Journal of Surgery 2010;37(12):808-811,封3
CountryChina
Language:Chinese
Abstract: Objective To study the expression of cyclooxygenase-2,epithelial cadherin and vascular endothelial growth factor-c in colorectal cancer and its significance. Methods Seventy-seven patients with colorectal cancer were detected the expression of COX-2, E-ca nd VEGF-c by immunohistochemical SP method. Results COX-2 positive expression in colorectal cancer tissue was 24.7%; E-ca positive expression rate of 68.8%; VEGF-c expression rate of 84.4%. COX-2 in highly differentiated cancer tissues was significantly higher than in poorly differentiated ones (P ＜0. 05); E-ca in the tubular adenocarcinoma was higher than in the mucous glands cancer and other types of cancer ( P ＜ 0. 05 ); The Positive expression rate of E-ca in the stage Ⅰ + Ⅱ was significantly higher than stage Ⅲ + Ⅳ (P ＜0. 005). COX-2 protein expression and VEGF-c expression was negatively correlated (P ＜ 0. 05 ). Conclusion Combined detection of COX-2,VEGF-c and E-ca is helpful to recognize the occurrence, development and tratment of colorectal cancer.