Clinical significance expression of MMP-7 in patients with primary non-small cell lung cancer
- VernacularTitle:基质金属蛋白酶7在非小细胞肺癌中表达的临床意义
- Author:
Fucai HAN
;
Binbin SHAN
;
Xiaozhen CHENG
;
Haibo ZHU
;
Wei GUO
;
Qinxiang GUO
;
Ruifen TIAN
;
Wenzhong SU
- Publication Type:Journal Article
- Keywords:
Carcinoma,Non-small cell lung;
Matrix metalloproteinases 7
- From:
Cancer Research and Clinic
2008;20(11):743-744,748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between expression of matrix metalloproteinases-7 (MMP-7) and clinicopathological characteristics in patients with primary non-smaU cell lung cancer(NSCLC). Methods MMP-7 in 20 normal people and 60 advanced NSCLC patiens were detected with reverse-transcription-polymerase-chain-reaction. Gelatum image analysator analyzed the result. Results The amount of MMP-7 was less in normal people (30.000) than in NSCLC patients(41.231) significantly(P<0.05); the level of MMP-7 was no correlated with gender, age, pathology pattern, tumor size, was inverse correlation with differentiation, and was positive correlation with clinical stages(P <0.05). Conclusion The level of MMP-7 is closely correlated with tissue differentiation and clinical stages of NSCLC, which may serve as a parameter for determining tumor invasion and metastatic.
