Experimental research on T cell vaccination combined with FK506 against the rejection heterogenic transplantation on peripheral nerve
10.3760/cma.j.issn.1001-2036.2009.01.018
- VernacularTitle:T细胞疫苗联合FK506抑制异种神经移植排斥的实验研究
- Author:
Jiabing SUN
;
Laijin LU
- Publication Type:Journal Article
- Keywords:
T cell vaccination;
FK506;
Heterogenic transplantation;
Peripheral nerve
- From:
Chinese Journal of Microsurgery
2009;32(1):43-46,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-rejection effect of T cell vaccination combined with FK506 of heterogenic transplantation on rat nerve. Methods SD rats were vaccinated by the spleen cells of BABL/c mice; T cell vaccines were activated and vaccinated in the spleen cells of these SD rats. The SD rats of nerve transplantation recipient were vaccinated with T cells combined with FKS06. The mixture lymphocytes culture, microcytotoxicity assay, histological alteration of nerves, humid weights of tibial anterior muscle were observed to confirm the anti-rejection effect of T cell vaccination combined with FK506 treatment. Results The humid weights of tibial anterior muscle of the vaccinated rats combined with FKS06 treatment were statistically different from those in control group (P ＜ 0.05), and so as the index of rejection (e.g. lymphocytes transformation efficiency) (P ＜ 0.05). Conclusion T cell vaccination combined with FK506 treatment can inhibit the rejection of heterogenic transplantation on rat peripheral nerve.
