Diagnostic value of combination of 99mTc-MIBI imaging,multi-slice spiral CT and tumor marker measurements for lung cancer

VernacularTitle:99mTc-MIBI肺显像、多排螺旋CT和肿瘤标志物检测对肺癌的诊断价值
Author: Guoji DANG
Publication Type:Journal Article
Keywords: Lung neoplasms; Tomography,emission computed,single photon; Tomography,X-ray computed; Carcinoembryonic antigen; Cytokeratin; Phosphopyruvatc hydratase
From: Cancer Research and Clinic 2009;21(3):172-173,177
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical value of the combination of three methods including 99mTc-MIBI imaging, multi-slice spiral CT and tumor markers [carcinoembryonic antigen(CEA),cytokeretin19 fragment(CYFRA21-1), neuron-specific enolase(NSE)] measurement for diagnosis of lung cancer. Methods 350 patients were performed 99mTc-MIBl imaging, multi-slice spiral CT and measurements of tumor markers apart within one week. 200 patients were proved by pathology lung cancer in all 350 patients. Results The sensitivity, specificity and accuracy obtained with the three methods and combination of three methods were 74.5 %(149/200), 68.7 %(103/150), 72.0 %(252/350);97.5 %(195/200), 42.7 %(64/150), 74.0 %(259/350);62.5 %(125/200), 28.7 %(43/150), 48.0 %(168/350) and 99.5 %(199/200), 82.0 %(123/150), 92.0 %(322/350),respectively. Conclusion The results imply that three methods has its distinct important clinical value in diagnosis of lung cancer respectively. The diagnostic efficacy of the combination of three methods is superior to any single one at present situation.