The importance of PTEN protein and CD44v6 detection to the prediction of laryngocarcinoma differentiation and cervical lymph node metastasis
10.3760/cma.j.issn.1006-9801.2009.06.010
- VernacularTitle:PTEN蛋白和CD44V6检测在提示喉癌分化程度和颈部淋巴结转移中的作用
- Author:
Ping LI
;
Naiwang WU
- Publication Type:Journal Article
- Keywords:
Laryngeal neoplasms;
PTEN phosphohydrolase;
Antigens,CD44v6;
Cell differentiation;
Neoplasms metastasis
- From:
Cancer Research and Clinic
2009;21(6):390-392,395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the importance of PTEN protein and CD44v6 detection to the prediction of laryngeal carcinoma differentiation and cervical lymph node metastasis. Methods The expressions of PTEN protein and CD44v6 were detected by immunohistochemical SP method in 97 specimens with laryngeal carcinoma and 97 specimens with a distance over 2.5 centimeters from laryngeal carcinoma. The relations between them and their clinical significance to the laryngeal squamous cell carcinoma above Glottis by the statistical analyses tools were revealed. Results The positive expression rates of PTEN protein were respectively 55.67 %, 100 % in laryngeal carcinoma and adjacent carcinoma tissue. There was a significant difference between them statistically (P<0.01). The positive expression rates of PTEN protein are notable difference among the high, middle and low differentiation of laryngeal carcinoma, but not between the positive metastasis of lymph node of neck and the negative one(P >0.05). For the expression of CD44v6, there were notable statistical difference not only among the different differentiation of laryngeal careinoma, but also between the positive metastasis of lymph node of neck and the negative one. The low expressions of PTEN protein and the high expression of CD44v6 in the same carcinoma cell has significant negative correlation (P< 0.05). Conclusion PTEN protein may have the importance to the differentiation of laryngeal carcinoma, but no means to cervical lymph node metastasis. CD44v6 may have great importance to both.
