Clinical significance of CD+4CDHi25CDLo127 regulatory T cell in the peripheral blood of patients with lung cancer

VernacularTitle:肺癌患者外周血CD+4CDHi25CDLo127调节性T细胞检测的临床意义
Author: Xiaoyu SHI ; Fucai LIU ; Wen SU
Publication Type:Journal Article
Keywords: Lung neoplasms; CD4+CD25HiCD127Lo; Regulatory T cells; IL-10; TGF-β
From: Cancer Research and Clinic 2009;21(7):453-454,457
CountryChina
Language:Chinese
Abstract: Objective To evaluate the changes and clinical significance of CD+4CDHi25CDLo127 regulatory T cell(Treg) in peripheral blood of patients with lung cancer. Methods 30 patients with lung cancer and 20 heathy volunteers were included in this study. The proportion of Treg population in CD4+ T cells stained with three colors was analysed by flow cytometry. The serum level of IL-10 and TGF-β were measured by ELISA. Results The proportion of Treg in patients with squamous cell careinoma(n=20), adenocarcinoma (n=10) were all significantly higher than that of healthy controls (P <0.05), but there was not obvious difference between the two groups with different pathological types(P0.05). Increased serum level of IL-10 and TGF-β was also detected in lung cancer patients. Conclusion The proportion of Treg is increased in lung cancer patients, which may result in the inhibition of host anti-cancer immune response by excreting IL-10 and TGF-β.