Expressions of ER, PR and Her-2 in breast cancer
10.3760/cma.j.issn.1006-9801.2009.07.010
- VernacularTitle:ER、PR、Her-2在乳腺癌中的表达
- Author:
Xi SHI
;
Xiaoyan LIN
;
Yi HUANG
;
Zhifeng ZHANG
;
Rixiong WANG
;
Wucha ZENG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
ER;
PR;
Receptor,Her-2
- From:
Cancer Research and Clinic
2009;21(7):461-462,465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between expressions of estrogen receptor (ER), progesterone receptor(PR) and human epidermal growth factor receptor 2 (Her-2) in 311 cases of breast cancer tissue and their clinical feature. Methods The expressions of ER, PR and Her-2 were detected by immunohistochemistry in 311 cases of breast cancer tissue proved pathologically. Results The positive rate of ER, PR and Her-2 were 59.49 %, 62.70 % and 27.97 % respectively in breast cancer tissues. Compared with non-invasive breast cancer, the expressions of ER and PR significant decreased in invasive breast cancer (P<0.05). The expression of ER decreased to follow the elevation of TNM status of breast cancer (P<0.05). Compared with patients who had not metastasis in axiUary lymph node, the expressions of ER significantly decreased and the expressions of Her-2 significantly increased in patients who had metastasis in axillary lymph node (P<0.05). Conclusion These findings indicate that ER, PR and Her-2 are intimate correlation with clinical feature and maybe participate in biological behaviour regulation of breast cancer. The routine detecting of ER, PR and Her-2 may provide the evidence for breast cancer treatment.
