Expression of VEGF -C and p63 in early esophageal carcinoma and intraepithelial neoplasia
10.3760/cma.j.issn.1006-9801.2009.11.015
- VernacularTitle:血管内皮生长因子-C及p63在早期食管癌和上皮瘤变组织中的表达
- Author:
Songyan HAN
;
Li LI
;
Ruifang SUN
;
Suhong LI
;
Ziyan HAN
;
Ming ZHAO
;
Quanhong WANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Carcinoma in situ;
Vascular endothelial growth factor C;
p63;
Immunohistochemistry
- From:
Cancer Research and Clinic
2009;21(11):762-764,771
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore expression and clinical value of VEGF-C and p63 in early esophageal carcinoma and intraepithelial neoplasia. Methods 146 cases were randomized into normal esophageal mucosa, low level intraepithelial tumor, high level intraepithelial tumor and early esophageal carcinoma. The expression of VEGF-C and p63 were detected by using the immunohistochemistry dyeing.Results The expression of VEGF-C immunohistochemistry dyeing had statistical differences among different levels(X~2= 47.455, P <0.001). Normal esophageal mucosa v.s. high level intraepithelial tumor (X~2=36.721, P <0.001), Normal esophageal mucosa v.s. early esophageal carcinoma (X~2=26.483, P <0.001), low level intraepithelial tumor v.s. high level intraepithelial tumor(X~2= 10.025, P<0.0083), low level intraepithelial tumor v.s. early esophageal carcinoma(X~2=16.734, P<0.001). There was a significant correlation between pathological classification and the expression amount of VEGF-C (r = 0.462, P <0.001). The expression of p63 had statistical differences among different levels(X~2=28.962, P <0.05). There was a significant difference on normal esophageal mucosa comparing with low level, high level intraepithelial tumor or early esophageal carcinoma (X~2=12.735, P =0.005, X~2=20.421, P<0.001, X~2=20.854, P<0.001). There was a significant correlation between pathological classification and the expression of p63 (r= 0.272, P<0.05). Conclusion There is a significant correlation in the express of either VEGF-C or p63 comparing with either intraepithelial tumor or early esophageal carcinoma. It may be an early warning indicator.
