Intraoperative iodine-125 seed implantation for pancreatic carcinoma
10.3760/cma.j.issn.1006-9801.2010.10.007
- VernacularTitle:术中125I放射性粒子植入治疗胰腺癌18例
- Author:
Fuzhen QI
;
Mingde HUANG
;
Ping ZHANG
;
Jianhuai ZHANG
;
Jianxiong WU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Brachytherapy;
3-Iodobenxylguanidine
- From:
Cancer Research and Clinic
2010;22(10):669-671,675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of intraoperative iodine-125 seed implanttation in treating pancreatic carcinoma. Methods Seventy-five patients (fourty-one men, thirty-four women;median age 54 years) with pancreatic adenocarcinoma were enrolled into the study. Thirty-one patients (group A) were accepted tumor resection,eighteen patients(group B) were implanted radioactive iodine-125 seeds into the tumors by a combination of bypass surgery, twenty-six patients(group C) were treated by bypass surgery.Results Sixty-seven patients were followed up. The median survival time was 19, 12 and 7 months in group A,B,C respectively, among which the difference was significant (P < 0.05). The response rate(CR+PR) was 50 % and the effective rate of pain relieving was 80% in the group B. The 97.4 % of accordance rate of seed number was demonstrated by CT film, but the accordance rate of seed space distribution was only 56 %.Conclusion At present, the active resection of the pancreatic carcinoma, including the superior mesenteric vein and the retropancreatic fusion fascia, is essential for a curative resection. The combination of Intraoperative iodine-125 brachytherapy and bypass surgery is safe and effective for pancreatic carcinoma.The seed space distribution completed by seed computer therapeutic plan needs further study.