Expression of p16, cyclinD1 protein and clinicopathological significance in esophageal squamous cell carcinoma
10.3760/cma.j.issn.1006-9801.2010.10.009
- VernacularTitle:食管鳞状细胞癌中p16和cyclinD1的表达及其临床意义
- Author:
Xuanqin YANG
;
Suhong LI
;
Jianhong LIAN
;
Ruifang SUN
;
Li LI
;
Quanhong WANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Neoplasms,squamous cell;
Genes,p16
- From:
Cancer Research and Clinic
2010;22(10):676-677,680
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of p16, cyclinD1 protein in esophageal squamous cell carcinoma and its clinic significance. Methods The expressions of p16 and cyclinD1 protein in 55 esophageal carcinoma cases were detected by immunohistochemical technique. Results The positive expression of p16 protein in 55 patients was 49.1%(27/55). The loss of p16 protein was significantly related to lymph node metastasis (P ＜0.05), and the positive expression of p16 had the higher five-year survival rate.Conversely, the positive expression of cyclinD1 in 55 patients was 74.5 % (41/55), and had the lower five-year survival rate compared to the negative expression cases. Conclusion Loss of p16 protein in human ESCC is a frequent event and correlates significantly with the lymph node metastasis. The loss of p16 and the over expression of cyclinD 1 in esophageal carcinoma may serve as a risk prognosis factors.
