Evaluation of the effects of LASIK rectification for refractive errors in children
10.3760/cma.j.issn.1006-1924.2010.06.022
- VernacularTitle:LASIK矫治儿童屈光不正效果的文献分析
- Author:
Pengfei LIU
;
Lin XIAO
- Publication Type:Journal Article
- Keywords:
Laser in situ keratomileusis;
Pediatric refractive errors;
Amblyopia;
Myopia;
Hyperopia;
Anisometropia;
Document analysis
- From:
Chinese Journal of Medical Science Research Management
2010;23(6):418-421,425
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the effects of LASIK ( laser in situ keratomileusis) rectification for pediatric refractive errors. Methods MEDLINE, Embase, the Cochrane library, Chinese Journal Full-text Database and Chinese Biomedical Literature Database were searched for related literatures in Chinese and English languages. A meta-analysis was performed based on the results. Results This study included 256 eyes (255 patients) from 12 independent researches. Meta-analysis showed postoperation corrected vision improved significantly ( WMD=-0.22, CI: -0.26 ～ -0.19, P＜0.00001 ) and LASIK was safe in children. But, considering heterogeneity among articles, Random effect model was applied and revealed the heterogeneity was a little large and the results had a certain bias ( I2 =46.3% ,close to 50% ). Conclusion Current studies have shown that LASIK plays a positive role in children while the safety and predictability have not yet been clear.Moreover, there lacks enough evidence to assess the middle-and long-term efficacy. Thus, more large scale,long-term, randomized control trials should be launched to evaluate the positive and negtive aspects of LASIK in pediatric refractive errors.
