Relationship and prognostic study between E-cadherin gene expression and lymphatic hyperplastic reaction in gastric cancer
10.3760/cma.j.issn.1006-9801.2010.11.006
- VernacularTitle:胃癌淋巴组织增生与上皮钙黏蛋白表达的关系及其预后意义
- Author:
Yangkun WANG
;
Chunfang GAO
;
Tian YUN
;
Xianwei ZHANG
;
Fulin LI
;
Xuexia Lü
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Lymph nodes;
Hyperplasia;
Neoplasm metastasis;
E-cadherin;
Prognosis;
Immunohistochemistry
- From:
Cancer Research and Clinic
2010;22(11):736-738,741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship and prognosis between E-cadherin gene expression and lymphatic hyperplastic reaction in gastric cancer. Methods The degree of lymphocytosis and draining lymph node from 86 cases of gastric cancer were observed and the expression of E-cadherin gene in gastric cancer were detected by SP method of immunohistochemistry (IHC). Results Lymphocyte infiltration degree around gastric cancers was positively related to the reactive hyperplasia of the lymphnodes and was inversely related to lymphatic metastasis. The expression of E-cadherin has relationship with the infiltration degree of stomach carcinoma. To compare with T1/T2 and T3/T4 phases, the result is significantly different (P ＜0.01).Meanwhile, the expression of E-cadherin was positively correlated with tumor-infiltrated lymphocytes and reactive hyperplasia of the lymph nodes, was negatively correlated with lymphatic metastasis in drainage area.Conclusion The over-expression of E-cadherin gene is significantly related to lymphoproliferation and lymph node metastasis. The abnormal expression of E-cadherin can be used as an index to determine prognosis of gastric carcinoma.
