Relationship between the expression of E-cadherin, CD44v6 and VEGF-C and lymph node metastasis in esophageal carcinoma
10.3760/cma.j.issn.1006-9801.2010.11.012
- VernacularTitle:食管癌组织中上皮钙黏素、CD44v6和血管内皮生长因子C表达与淋巴结转移的关系
- Author:
Hongyuan WANG
;
Hongjun FEI
;
Yajing LIANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
E-cadherin;
CD44v6;
Vascular endothelial growth factor C;
Immunohistochemistry
- From:
Cancer Research and Clinic
2010;22(11):755-757,760
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of E-cadherin (E-cad), CD44v6 and VEGF-C in esophageal carcinoma and investigate their relationship with lymph node metastasis. Methods The expression of E-cad, CD44v6 and VEGF-C was detected with immunohistochemical EnVision method in 56cases of esophageal carcinoma and 12 cases of normal esophageal mucosa. Results Among 56 cases of esophageal carcinoma, the positive expression rates of E-cad in esophageal carcinoma was 55.4 %(31/56),significantly lower than that in normal esophageal mucosa 100.0 %(12/12) (P ＜0.05). The positive expression rates of CD44v6 and VEGF-C were 71.4 % (40/56) and 62.5 % (35/56), significantly higher than that in normal esophageal mucosa (P ＜0.05). The positive rates of E-cad was 31.3 % (10/32) in the group of positive lymph node metastasis, significantly lower than that in the group of positive non-lymph-node metastasis 87.5 % (21/24) (P＜0.05). The positive rates of CD44v6 and VEGF-C were 84.4 % (27/32) and 75.0 % (24/32) in the group of positive lymph node metastasis ,significantly higher than that in the group of positive non-lymph-node metastasis 54.2 % (13/24) and 45.8 %(11/24) (P＜0.05). E-cad was negatively correlated with lymph node metastasis; CD44v6 and VEGF-C were positively correlated with lymph node metastasis (P ＜0.05). Conclusion E-cad, CD44v6 and VEGF-C play important roles in the process of soakage and metastasis of esophageal carcinoma. The combined detection of E-cad, CD44v6 and VEGF-C can help to prodict biological behaviors and prognosis of esophageal carcinoma.
