Effect of curcumin on serum levels of gelatinases in patients with unstable angina pectoris

VernacularTitle:姜黄素对不稳定型心绞痛患者血清明胶酶水平的影响
Author: Meihua JIN ; Chunhui LIU ; Aixin LI
Publication Type:Journal Article
Keywords: Curcumin; Gelatinases; Angina pectoris,Unstable
From: Chinese Journal of cardiovascular Rehabilitation Medicine 2011;20(3):277-279
CountryChina
Language:English
Abstract: Objective: To investigate effect of curcumin on serum gelatinases levels in patients with unstable angina pectoris（UAP）. Methods： A total of 80 UAP patients admitted from January 2010 to September 2010 were enrolled and randomly divided into curcumin treatment group (n=40) and routine treatment control group (n=40). Serum levels of gelatinases [contain matrix metalloproteinase（MMP）-2 and -9) of the two groups were measured before and 30d after treatment. Results：Compared with before treatment , after treatment, serum gelatinases levels significantly decreased [MMP-2：（52.64±6.77）ng/ml vs. （32.65±1.67）ng/ml，MMP-9：（56.75±7.34）ng/ml vs.（35±1.88）ng/ml ] (P<0.01) in curcumin treatment group (P<0.01), and they were significantly lower than those of routine treatment control group [MMP-2：（32.65±1.67）ng/ml vs.（37.78±2.76）ng/ml，MMP-9：（35±1.88）ng/ml vs.（40.23±1.95）ng/ml ] , P<0.05 all. Conclusion：Curcumin could decrease serum levels of gelatinases in patients with unstable angina pectoris, and possesses effect of stabilization coronary artery plaque.
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