Therapeutic effect of creatine phosphate in early diastolic dysfunction
- VernacularTitle:磷酸肌酸对早期舒张功能障碍的疗效
- Author:
Ying WANG
;
Yuli CHEN
;
Linqing MA
;
Fengchun LI
;
Bing WANG
;
Lili ZHU
;
Wei YI
;
Yujuan CUI
;
Nagai YOKO
;
Sakamoto SHINGO
- Publication Type:Journal Article
- Keywords:
Heart failure, congestive;
Phosphocreatine;
Treatment outcome
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2010;19(5):501-506
- CountryChina
- Language:English
-
Abstract:
Objective: To investigate the therapeutic effect of creatine phosphate sodium (CP, Neoton) at early stage of myocardium diastolic dysfunction. Methods: A total of 138 cases with myocardium diastolic dysfunction were divided into CP group (n=109) and routine treatment group (n=29). All the patients received routine treatment. The CP group received CP treatment based on routine treatment(CP 2g+5%glucose or 0.9% sodium chloride 100ml, iv. drip, for patients with mild diastolic dysfunction was 1time/d, patients with moderate diastolic dysfunction was 2 times/d), duration was 7~14 days. Color-coded Doppler echocardiography was used to detect transmitral peak early diastolic velocity (E-wave)，transmitral peak late diastolic velocity (A-wave)，peak early diastolic velocity of mitral annulus (Ea), and peak late diastolic velocity of mitral annulus(Aa), and the value of E/A ,Ea/Aa and E/Ea were calculated. Symptoms, signs and items from echocardiography were compared between the two groups before and after treatment. Results: After treatment, all symptoms and signs of patients in two groups significantly improved (P<0.05~0.01), and the marked effective rate in CP group was significantly higher than that of routine treatment group (96.2% vs. 57.1%, P<0.01). In CP group, the marked effective rate of E/A (81.65% vs. 10.34%), Ea/Aa (83.49% vs. 13.79%) and E/Ea (92.86% vs. 12.00%) were significantly higher than those in routine treatment group (P<0.01all). Conclusion: Creatine phosphate possesses marked effect for improve patient’s condition and diastolic dysfunction.
- Full text:P020101105575529689688.doc
