Polymorphism of CTLA-4 gene in SLE patients and its association with ANA or anti-dsDNA antibody
- VernacularTitle:SLE患者CTLA-4基因多态性与ANA、抗dsDNA抗体相关性研究
- Author:
Yan ZHOU
;
Linsheng XIAO
- Publication Type:Journal Article
- Keywords:
cytotoxic T lymphocyte-associated antigen 4;
gene polymorphisms;
systemic lupus erythematosus;
ANA;
anti-dsDNA antibody
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between systemic lupus erythematosus(SLE) and polymorphism of cytotoxic T-lymphocyte antigen 4 gene(CTLA-4) and the effect on ANA and anti-dsDNA antibody.Methods The A/G substitution was investigated in the exon 1 position 49 in 92 SLE patients and 60 controls by PCR restriction fragment length polymorphism(PCR-RFLP).ANA and anti-dsDNA antibody were examined by indirect fluorescence immunoassay.Results SLE patients had significantly higher frequencies of the CTLA-4+49GG allele than controls(P
