Progress in the study of triple negative breast cancer
- VernacularTitle:三阴性乳腺癌的研究进展
- Author:
Jun GU
;
Zeping YU
;
Ning LI
- Publication Type:Journal Article
- Keywords:
Triple negative breast cancer;
Basal-like breast cancer;
Breast cancer susceptibility gene;
Prognosis;
Therapy
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Triple-negative breast cancer (TNBC) is a subgroup of breast cancers defined by a lack of the expressions of estrogen,progesterone and HER2 receptors,with more aggressive biological and clinicopathological characteristics and a close relationship with basal-like and breast cancer susceptibility gene-1 (BRCA1)-related breast cancers.TNBC is insensitive to most available hormonal or standard therapeutic agents,associated with increased risk for distant metastases and with poorer prognosis than other types of breast cancer.A deeper insight into the biology of TNBC may lead to improved therapies and better clinical outcomes of the disease.
