Immunomodulatory features of chemotherapeutics
- VernacularTitle:化疗药物的免疫调节作用
- Author:
Xiang HUANG
;
Longbang CHEN
- Publication Type:Journal Article
- Keywords:
Tumor;
Immune escape;
Chemotherapeutics preconditioning regimen;
Immune modulation;
Immunotherapy
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapeutic drugs conventionally used for their cytotoxic activity can also exert their influence on the immune system by grooming the tumor microenvironment,abrogating immune tolerance and inciting immune reconstitution.Due to their immunomodulatory features,chemotherapeutics,used as a preconditioning regimen and combined with subsequent immunotherapy,can mobilize the immune system to generate antitumor immune response.The synergy between chemotherapy and immunotherapy has brought some enlightenment to the development of new protocols for cancer treatment.
