Progress on aberrant methylation of INK4a/ARF and ASPP genes in tumor
- VernacularTitle:肿瘤中INK4a/ARF和ASPP基因异常甲基化的研究进展
- Author:
Hongling LI
;
Chunhua ZHAO
- Publication Type:Journal Article
- Keywords:
INK4a/ARF;
ASPP;
methylation;
DNMTs
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Many tumorigenesis in human are closely linked to the functional loss of P53. The tumor-suppressive functions of P53 are abrogated by mutations,but in 50% of all tumors it remains wild type. In these cases,loss of P53 tumor-suppressive function mainly results from the abnormal methylation of 5' CpG islands of tumor suppressor genes such as INK4a,ARF and ASPP. Restoring to normal methylation state of these genes might provide a new strategy for tumor therapy.
