Profile of pathology in rabbit unstable plaque with ~(18)F-FDG PET/CT detection
- VernacularTitle:兔不稳定斑块的~(18)F-FDG PET/CT显像及其病理学检测
- Author:
Dandan ZHANG
;
Zhanmin XU
;
Aili SONG
;
Quanming ZHAO
;
Xiaoli DONG
- Publication Type:Journal Article
- Keywords:
18F-FDG PET/CT;
unstable plaque;
macrophage;
smooth muscle cell
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the feasibility of noninvasive detection of unstable plaques with 18F-Fluorodeoxyglucose (18F-FDG) PET/CT imaging. Methods Atherosclerotic plaques were induced in male New Zealand white rabbits. Animals were injected with FDG labeled with 18F,then examined with PET/CT. Aorta was explanted for photography with digital camera,and 18F-FDG uptake analysis. Thirty unstable plaques and 30 stable plaques were choosed so as to compare the quantitativly 18F-FDG uptake.The number of macrophages and smooth muscle cells was detected by immunohistochemical technique. Results Experimental group showed inconsistent uptake of 18F-FDG in the abdominal aorta. The results were confirmed in the ex vivo digital photo of the explanted aorta. The target to non target ratio(T/NT) and macrophages of unstable plaques were higher than stable plaques(P
