Alleviative effects of lidocaine postconditioning on pulmonary ischemia-reperfusion injury of rats
- VernacularTitle:利多卡因后处理减轻大鼠肺缺血再灌注损伤
- Author:
Mao XU
;
Feng GAO
;
Xiangyang GUO
- Publication Type:Journal Article
- Keywords:
ischemia reperfusion;
lidocaine;
postconditioning;
pulmonary
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the alleviative effects of lidocaine postconditioning on pulmonary injury following ischemia reperfusion.Methods Seventy-two adult SD rats were randomized to 4 groups:sham group,ischemia-reperfusion(I-R) group,ischemic postconditioning(IPC) group and lidocaine postconditioning group. The pulmonary ischemia-reperfusion model was established by occlusion of the left hilum of lung for 45 min and the reperfusion was taken by removing the clamp for 2 h. At the moment of reperfusion,lidocaine 4 mg/kg was injected as a priming dose following a continuous rate of 4 mg/(kg?h). PaO2,TNF-?,W/D of left lung,the level of MDA of left lung tissue were measured. At the end of reperfusion left lung was removed for microscopy. Results After reperfusion PaO2 of lidocaine group was much higher than that of I-R group(P
