Clinical significance of hypoxia inducible factor-1α expression on postoperative adjuvant radiotherapy in esophageal carcinoma
10.3760/cma.j.issn.1006-9801.2010.05.009
- VernacularTitle:缺氧诱导因子蛋白表达对食管癌术后辅助治疗的临床意义
- Author:
Zhichao FU
;
Huihua CHENG
;
Dongshi LI
;
Congwen ZHUANG
;
Qinghong LIU
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
HIF-1α;
Radiotherapy,computer-assisted;
Adjuant radiotherapy;
Prognosis
- From:
Cancer Research and Clinic
2010;22(5):312-314,318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of hypoxia inducible factor-1α(HIF-1α) expression on postoperative adjuvant radiotherapy in esophageal carcinoma. Methods 95 cases with esophageal carcinoms who received radical operation were analyzed with followed-up data from 1995 to 1998.Expression of HIF-1α in 45 patients with esophageal carcinoma who received radiotherapy after radical operation were deternlined by immunohistochemical method in contrast with 50 patients with esophageal carcinoma received surgery alone.Kaplan-Meier method and COX proportional hazard model were used to analyze.Results The positive expression of HIF-1α in esophageal carcinoma was observed mainly in the nucleus of tumor cells.The positive expression rate of HIF-1α in esophageal carcinoma was 58.9%.The expression of HIF-1α had no relationship with age,sex,histologic subtype and T stage,but had positive relationship with recurrence and distant metastasis.There was significant difference between patients with positive and negative HIF-1α protein expression in surgery alone and postoperation radiotherapy group. COX model analysis showed that HIF-1α had separate and significant impacts on prognosis in surgery group and surgery plus radiotherapy group. Conclusion Over expression of HIF-1α protein suggests a poor prognosis,and has tendency to resist radiotherapy in esophageal carcinoma.
