Paeoniflorin increases ?-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis
- VernacularTitle:芍药苷增高小鼠恶唑酮结肠炎黏膜中?-防御素表达并减轻病变
- Author:
Yi ZHOU
;
He WANG
;
Yueshan LI
;
Yiwen TAO
;
Jianye ZHANG
;
Zhiqiang ZHANG
- Publication Type:Journal Article
- Keywords:
paeoniflorin;
?-defensin;
IL-6;
IL-10;
oxazolone-induced colitis
- From:
Acta Pharmaceutica Sinica
2010;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Previous studies have demonstrated that the Chinese medicine paeoniflorin, derived from the Ranunculaceae plant peony, peony, purple peony root, was able to have anti-inflammatory, anti-ulcer, anti- hypersusceptibility and anti-oxidation activity. In order to elucidate the pesticide effect and the mechanisms by which paeoniflorin exerts its effect of anti-inflammation and immunoregulation on oxazolone-induced colitic mice, disease activity index (DAI) and histological grading of colitis (HGC) were evaluated in animal model. Moreover, the expressions of HBD-2, IL-6 and IL-10 of mice with experimental colitis were observed with immunohistochemistry and RT-PCR in this study. Results showed that DAI and HGC of oxazolone control group was significantly higher than that of normal control group, and that paeoniflorin groups and 5-ASA group, compared with oxazolone control group, could alleviate the symptoms and histological damages of colitic mice (P
