Clinicopathologic characteristics of primary squamous cell carcinoma of the breast

VernacularTitle:乳腺原发性鳞状胞癌 16例临床病理分析
Author: Shunhai JIAN ; Bin WEN ; Yifan HUANG
Publication Type:Journal Article
Keywords: Breast neoplasms; Carcinoma,squamous cell; Neoplasms,second primary
From: Cancer Research and Clinic 2010;22(3):161-163,167
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinicopathologic and immunohistochemicalcharacteristics of primary squamous cell carcinoma of the breast(PSCCB). Methods Sixteen patients with primary squamous cell carcinoma of the breast were retrospectively reviewed. Twelve cases with a follow-up information were evaluated for ER, PR, C-erbB-2, HCK, Ki-67 expression. Results PSCCB is a very rare neoplasm,constituting 0.8 % of all breast carcinoma over 28 years(1981-2008) in our hospital. The patients age varied from 25 to 72, median age is 49 years old. All patients received operative treatment. Seven patients had metastatic disease in axillary lymph nodes. Three patients died from metastases and tumour recurrence.Tumors were usually ER-negative, but most cases showed high molecular cytokeratin (HCK) expression.Conclusion In terms of the clinical feature, there were no differences between the PSCCB and the other breast cancer. PSCCB could be confirmed by pathology. The prognosis is in controversial. Standard therapy should be studied and recommended in future.