Inhibitory effects of Okam extract on bleomycin induced pulmonary fibrosis in rats
- VernacularTitle:昆布提取物抑制大鼠肺纤维化的研究
- Author:
Handong JIANG
- Publication Type:Journal Article
- Keywords:
Okam;
pulmonary fibrosis;
bleomycin;
vascular endothelial growth factor;
tumor necrosis factor-?
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-proliferative effects of Okam extract on bleomycin induced pulmonary fibrosis in rats and its underlying mechanisms.Methods Pulmonary fibrosis was induced in Wistar rats by intratracheal instillation of bleomycin.Then test groups received daily Okam at doses of 25 and 50 mg?kg~(-1) orally and control group received normal saline.The expressions of collagen-Ⅲ.tumor necrosis factor(TNF-?) and vascular endothelial growth factor(VEGF) proteins were determined by immunohistochemistry.Results Pulmonary fibrosis of test groups was improved as compared with that of model group.Protein expressions of collagen-ll,VEGF and TNF-?in 50mg?kg~(-1)group were markedly lower than those in model group.Protein expressions of collagen-Ⅲand VEGF in 25 mg?kg~(-1)group were lower than those in model group,while protein expression of TNF-?showed no difference with that in model group.Conclusion Okam extract alleviates bleomycin induced pulmonary fibrosis in rats by inhibiting the expressions of collagen-Ⅲ,TNF-?and VEGF.
