Clinical characteristics of low rectal carcinoma with preoperative 30 Gy radiation

VernacularTitle:低位直肠癌术前加速放疗的临床意义
Author: Mingxiao CHEN ; Li FAN ; Xiaobo LIANG ; Yanping WANG
Publication Type:Journal Article
Keywords: Rectal neoplasms; Radiotherapy,computer-assisted; Pathology,clinical
From: Cancer Research and Clinic 2010;22(5):306-307,311
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical pathological changes lower rectal carcinoma after preoperative radiation.Methods Thirty cases of rectal carcinoma underwent preoperative radiotherapy at a dose of 30 Gy.Gross size of the tumors was measured and histological changes were analyzed before and after radiation.Results The rates of complete regression,partial regression and no response to radiation of the tumors were 23.3%.53.3%and 23.3%.Significant tumor regression RCRG Ⅲ wag seen in 6 cages (20.0%) after radiotherapy.while partially tumor regression RCRG Ⅱ was seen in 15 cases (50.0%). Conclusion Preoperative radiation at a dose of 30 Gy on lower rectal carcinoma induces degeneration and necrosis of the tumor cells with complete or partial regression in most cases.Necrosis,fibrosis and thickening of vascular intima in the rectal cancer tissue after radiotherapy is more frequent than those without radiotherapy.It may be the potential reason for increased resection rate and sphincter saving after radiotherapy. It hag a great significance for sphincter-preservation surgery in this group of rectal carcinomas.