Effects of berberine on the prevention of left ventricular remodeling after acute myocardial infarction
- VernacularTitle:小檗碱抑制心肌梗死后心室重构的作用
- Author:
Xiaofeng ZHU
;
Zhizhong LIU
;
Jing XU
- Publication Type:Journal Article
- Keywords:
Berberine;
Myocardial infarction;
Left ventricular remodeling;
Matrix metalloproteinases
- From:
Chinese Journal of Interventional Cardiology
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of berberine(BBR)on the prevention of left ventricular remodeling after acute myocardial infarction(AMI)in New Zealand rabbits.Methods AMI were conducted by ligating left coronary artery in female New Zealand rabbits.Five days after the procedure,the 28 survival rabbits were randomized into the controls(n=14)or BBR treatment group [n=14,BBR 8 mg/(kg?d)iv.].Hemodynamic studies were performed 4 weeks after the completion of treatment.Pathology study of the rabbits hearts was carried ont and matrix metalloproteinases(MMPs)2 and 9 were detected by immunohistochemical analysis in the non-infarct myocardium.Results Compared with the control group,left ventricular relative weight(LVRW)and LV end diastolic pressure(LVEDP)were decreased in the treatment group 4 weeks after BBR intervention(1.55?0.12 vs 1.69?0.13,P
