Meta-analysis on Serological Effect of the Primary Vaccination for Japanese Encephalitis of the Literatures
- VernacularTitle:流行性乙型脑炎疫苗基础免疫血清学效果的Meta分析
- Author:
Zundong YIN
;
Huiming LUO
;
Yixing LI
- Publication Type:Journal Article
- Keywords:
Japanese encephalitis attenuated live vaccines;
Japanese encephalitis inactivated vaccine (Vero cell);
Japanese encephalitis inactivated vaccine (Primary Hamster Kidney Cell);
Serological effects;
Meta analysis
- From:
Chinese Journal of Vaccines and Immunization
2008;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To summary and compare the different seroconversion rates after the primary vaccination for the Japanese encephalitis (JE),and to evaluate the serological effect of 3 kinds of JE vaccines.Method Searching "CHKD","Wanfang" database and "EMCC" databases,the studies of the immunogenicity after the primary JEV vaccination,all randomized controlled trials or non-randomized controlled trials were included,and statistical analysis were made by RevMan 4.2.10 software.Results A total of 12 literatures were included,7 studies had control groups.The seroconversion rates after the primary vaccination,JEV-L,JEV-I (Vero) and JEV-I(PHK),were 86% (95% CI:80% ～ 91%),83% (95% CI:72% ～ 94%) and 64% (95% CI:58% ～ 69%) respectively.Comparing the seroconversion rates of the 3 kinds of vaccines after primary immunization,the rate of JEV-I (Vero) was significantly higher than the rate of JEVI(PHK),other comparisons were no significant difference.Conclusion The serological effects of JEV-L and JEV-I (Vero) after the primary vaccination were higher than that of JEV-I (PHK).
