Influence of mild hypothermia therapy on expression of heat shock proteins in lymphocyte in patients with severe craniacerebral injury
- VernacularTitle:亚低温治疗对重症颅脑损伤患者淋巴细胞中热休克蛋白表达的影响
- Author:
Zhijun HAO
;
Zunling LI
;
Bangping YUAN
- Publication Type:Journal Article
- Keywords:
mild hypothermia;
severe craniacerebral injury;
heat shock protein
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of mild hypothermia therapy on expression of heat shock protein(HSP)60,HSP70,HSP90 in lymphocyte in patients with severe craniacerebral injury.Methods 23 patients with severe craniacerebral injury were randomly divided into the mild hypothermia group (12 cases) and the normothermia group(11 cases).At the base of routine therapy,the mild hypothermia group received mild hypothermia therapy by the temperature control blanket to keep the body temperature among 32～34℃ for 4～6 d.The expression of HSP60,HSP70,HSP90 in lymphocyte were measured by Western Blot at the 1st d,4th d and 8th d after treatment.The infection incidence was observed at 7 d after treatment.And the expression of HSPs in lymphocyte at 32℃ and 37℃ in normal control group were measured respectively.Results Compared with normothermia group,the expression of HSP60 in mild hypothermia group was significantly lower at each time point(all P
