Correlation between the gene polymorphism of glucocorticoid receptor intron 4 G1666T and intracerebral hemorrhage
- VernacularTitle:糖皮质激素受体基因第4内含子G1666T多态性与脑出血的相关性
- Author:
Lanqin CHI
;
Ping WANG
;
Dewan SUN
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
glucocorticoid receptor;
gene polymorphism
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the gene polymorphism of glucocorticoid receptor intron 4 G1666T (GR G1666T) and intracerebral hemorrhage(ICH ).Methods Frequencies of genotypes and alleles of GR G1666T in 48 pations with ICH(ICH group),48 ICH patients combining essential hypertension(EH) (ICH+EH group),46 EH patients (EH group) and 71 healthy people (NC group) were analyzed by a polymerase chain reaction for restriction fragment length polymorphism (PCR-RFLP).The gender,body mass index(BMI),blood pressure(BP),the levels of plasma angiotensinogen,renin,blood glucoseand and blood lipid were compared among the various genotype of GR G1666T in ICH patients.Results There was no obviously difference of G1666T genotype and allele frequencie among the 4 groups.However,the G allele frequence of females in groups ICH,ICH+EH and EH were significantly higher than that in NC group(all P
