Relationship between the serum high-sensitivity C-reactive protein level,C-reactive protein 1059G/C gene polymorphism and cerebral infarction
- VernacularTitle:血清超敏C-反应蛋白水平及CRP 1059G/C基因多态性与脑梗死的相关性
- Author:
Ke DENG
;
Zhijie XIAO
;
Shuiping ZHAO
- Publication Type:Journal Article
- Keywords:
high-sensitivity C-reactive protein;
CRP 1059G/C gene polymorphism;
cerebral infarction
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the level of high-sensitivity C-reactive protein (hs-CRP),CRP 1059G/C gene polymorphism and cerebral infarction(CI).Methods The CRP 1059G/C genotype and allele frequencies were assayed by polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) in 105 patients with CI and 121 controls.The level of serum hs-CRP was detected by immune-turbidimetry.The relationship between the condition of CI patients,the level of serum hs-CRP and CRP 1059G/C genotype and allele frequencies were anaysed.Results Compared to the control group,the CRP 1059G/G genotype and G allele frequencies in CI group were statistically higher,G/C+C/C genotypes and C allele frequencies were statistically lower(all P
