Expermental study of Pioglitazone on treating vascular dementia
- VernacularTitle:吡格列酮治疗血管性痴呆的实验研究
- Author:
Minxia GUO
;
Ting WEI
;
Lu GAO
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator-activated receptor-?;
Pioglitazone;
vascular dementia;
neuroprotection
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of peroxisome proliferator-activated receptor-? (PPAR?) agonist Pioglitazone on treating the vascular dementia (VD) model.Methods SD rats were randomly divided into the sham-operated group,VD group,Pioglitazone high-dose group [20 mg/(kg?d)] and low-dose group [5 mg/(kg?d)].The VD models were made by modified Pulsinelli four-vessel occlusion method,and each group received corresponding treatment for 7 d.Then,Morris water maze test was applied to examine the place navigation escape latency.The number of PPAR? positive neurons and expression of PPAR? in the cerebral tissue were detected by immunohistochemistry.Results Compared to the VD group,the place navigation escape latencies in the two Pioglitazone treated groups were significantly shorter(all P
