Quinolone-resistance Genes in Multi-Drug-Resistant Klebsiella pneumoniae
- VernacularTitle:多药耐药肺炎克雷伯菌喹诺酮类耐药相关基因研究
- Author:
Jiarui MI
;
Zhimi HUANG
;
Zuhuang MI
- Publication Type:Journal Article
- Keywords:
Klebsiella pneumoniae;
Quinolone;
Drug-resistance gene
- From:
Chinese Journal of Nosocomiology
2009;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the quinolone-resistance mechanisms of multi-drug-resistant Klebsiella pneumoniae(MDRKP).METHODS Seven kinds of chromosome and plasmid mediated quinolone-resistance genes were analyzed by PCR and verified by DNA sequencing in 25 strains of MDRKP.RESULTS In 25 strains of MDRKP,the positive rate of genes of gyrA,aac(6′)-Ⅰb-Cr,qnrA1,qnrB4-like,qnrS1,mdfA,and qepA were 76.0%,36.0%,8.0%,8.0%,12.0%,100.0%,and 0,respectively.CONCLUSIONS The mutation of gyrA gene is the main cause of the resistance of quinolone in the 25 strains of MDRKP.
