Antinociceptive effect of botulinum toxin A on visceral pain in rats
- VernacularTitle:A型肉毒毒素对内脏性疼痛镇痛作用的实验研究
- Author:
Li LI
;
Qingsen LIU
;
Yunsheng YANG
- Publication Type:Journal Article
- Keywords:
Botulinum toxin type A;
Visceral pain;
Acetylcholine esterase;
Substance P
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: In recent years,botulinum toxin type A(BTX-A) has been investigated for the treatment of pain.This experiment was to investigate the antinociceptive effect of BTX-A intraperitoneal injection on visceral pain of rats and its effect on intestinal AChE and SP expression.Methods: 72 male adult Wistar rats were divided into four groups: BTX-A(2U,4U,and 6U) or vehicle(2ml) was injected intraperitoneally in B,C,D and A group.6 Rats of every group were challenged with acetic acid intraperitoneal injection after 1,4 and 8 weeks respectively.After abdominal writhing behaviors were monitored,the intestinal samples were immunohistochemical stained for AChE and SP examination.Results: At the end of one week,writhing test scores of rats in group C and D were decreased significantly compared with group A(P
