Changes of plasma TNF-? in the rats with isoproterenol-induced congestive heart failure
- VernacularTitle:异丙基肾上腺素充血性心力衰竭大鼠模型TNF-?的改变
- Author:
Zheng LI
;
Han GUO
;
Zhiming ZHAO
;
Junhao GUO
;
Hui CAI
- Publication Type:Journal Article
- Keywords:
Isoproterenol;
SD rats;
Chronic heart failure;
TNF-?;
Myocardial remodeling
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Recent studies have suggested that congestive heart failure(CHF) is related to neuroendocrine system and cytokines,and its activation contributes to myocardial remodeling and leads to the development and progression of CHF.Tumour necrosis factor-?(TNF-?) is one of the most important factors.This study intends to establish the animal model of isoproterenol(ISO)-induced CHF in rats and to study the changes of serum TNF-?.Methods:Male SD rats were randomly allocated to the ISO-induced CHF group(n=50) receiving two subcutaneous injections of 170mg ISO per kilogram of body and the healthy control group(n=10) receiving two subcutaneous injections of 0.25ml normal saline.At 18th week,the hemodynamic parameters including HR,LVSP,LVEDP and ?dp/dtmax were assessed.TNF-? in plasma were all detected.Results:Compared with the control group,the LVSP、?dp/dtmax significantly decreased and the HR,LVEDP enlarged notably in CHF group(P
