Anti-?2 integrin inhibits invasion and migration of osteosarcoma MG63 cells
- VernacularTitle:?2整合素抗体对人类骨肉瘤MG63细胞迁移侵袭的影响
- Author:
Wen GUO
;
Xiang LU
;
Xin SHI
;
Sujia WU
- Publication Type:Journal Article
- Keywords:
Osteosarcoma;
?2 integrin;
Migration;
Invasion;
MG63
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Changes in the ?2 integrin of adhesion molecules between cells are closely associated with the invasion and migration of tumor cells.This study aimed at the effect of anti-?2 integrin on the invasion and migration of osteosarcoma MG63 cells. Methods: The osteosarcoma MG63 cell line was cultured in the DMEM medium.The effect of the anti-?2 integrin monoclonal antibody on the migration and invasion of tumor cells were measured by scratch assay and Transwell assay.The migration and invasion cells were stained by Crystal violet staining and counted under the hundredfold microscope.Results: Compared with the control group,the migration and invasion abilities of the MG63 cells were significantly decreased in the anti-?2 treatment groups.Conclusion: Anti-?2 integrin may inhibit the migration and invasion of osteosarcoma cells.
