Puerarin reduces ethanol-induced-apoptosis of spermatogenic cells in rat testis
- VernacularTitle:葛根素减轻乙醇导致大鼠生精细胞的凋亡
- Author:
Hongyun HE
;
Yihao DENG
;
Xinwen YANG
;
Kaiming YANG
- Publication Type:Journal Article
- Keywords:
ethanol;
puerarin;
spermatogenic cells;
apoptosis
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate potential protection by protect against ethanol-induced apoptosis of spermatogenic cells in rat testis.Methods Thirty SD adult male rats were randomly divided into three groups: normal group,alcohol group and puerarin group.At 40th day,BCL-2 and BAX of spermatogenic cells of testis tissue were checked by RT-PCR and immunohistochemistry;Apoptosis of spermatogenic cells was determined by TUNEL.Results The results of RT-PCR and immunohistochemistry indicated that BCL-2 and BAX of spermatogenic cells were not significanty different between puerarin group and normal group,but there was the significant difference between alcohol group and puerarin group(P
