Time-domain Photoacoustic Tomography of Mouse Brain Vessel in Vivo
- VernacularTitle:活体白鼠脑血管时域光声成像的实验研究
- Author:
Tao LU
;
Huiyong MAO
;
Haihe ZANG
- Publication Type:Journal Article
- Keywords:
medical optics and biotechnology;
photoacoustic tomography;
unfocused ultrasound transducer;
brain vessel;
living tissue
- From:
Chinese Medical Equipment Journal
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To get photoacoustic (PA) image of vascular structure inside mouse brain in vivo.Methods A 532nm pulsed laser was used as the pumping source to generate PA signal,and a wide-band PVDF unfocused ultrasound transducer was used to collect time-domain PA signal by circular scan.PA signal recorded at each scanning position was then de-noised by wavelets transform using soft-thresholding.The PA image of the mouse brain vessel was reconstructed by time-domain spherical back projection algorithm.Results PA image agreed well with the histological picture of mouse brain vessel.Conclusion The experimental result indicates the potential value of clinical application.
