Analysis of levels of microelements as biomarker in injury induced by formaldehyde
- VernacularTitle:微量元素作为甲醛损伤生物标志物的水平分析
- Author:
Jinghong YU
;
Huan LI
;
Weiqi SUN
;
Xiaolei XU
;
Jiuchun GAO
- Publication Type:Journal Article
- Keywords:
formaldehyde;
microelements;
biomarker
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of formaldehyde on the level of microelements in mouse liver and blood and explore the microelements as biomarker in injury induced by formaldehyde.Methods The mice were randomly divided into control,low(1/40LD50),moderate(1/20LD50) and high(1/10LD50) dose groups exposed to formaldehyde by inhalation(n=20),two hours per day for three and six weeks,and than the contents of Cu,Fe,Zn and Mn in mouse liver and blood were measured.Results The contents of Fe,Zn and Mn in liver in high dose group three weeks after exposure and the contents of Fe and Zn in liver in high dose group six weeks after exposure were significantly lower than those in control group(P
