Analgesia effect of Tongbiding free-dried powder for injection on spinal cord center and its mechanism
- VernacularTitle:痛必定冻干粉针对脊髓中枢的镇痛作用及其机制
- Author:
Jun CAO
;
Zhongnan WANG
;
Shujuan SUN
- Publication Type:Journal Article
- Keywords:
Tongbiding freezing and drying medicine powder;
CCI model rat;
WDR neuron;
electricity activity
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Tongbiding freezing-dryied powder for injection on the function of WDR neuron of spinal cord in living rats with chronic constriction injury (CCI),and clarify its analgesia mechanism in spinal cord center,and further explore whether it has the drug dependence at the cellular level. Methods Electricity physiology extracellular recording technique was used ,in the CCI living rat's expanded spinal cord waist stage the electricity activity of identical WDR neuron cells was recorded before and after administration of 20 mg?kg-1 Tongbiding. The electric discharge number of C response was observed before and 2,4,8,10 min after administration. The spontaneous electric discharge number. was observed before and 1,2,4,6 min after administration; wind-up phenomenon was also observed.Results The electric discharge number of C response was obtained in 8 WDR neurons,three were significant differences of the mean electric discharge number of C response between 2,4,8 min after administration and before administration (P
