Changes of Th1/Th2 cytokines levels in serum in patients with chronic hepatitis B before and after treatment of thymosin
- VernacularTitle:慢性乙型肝炎患者胸腺肽治疗前后血清Th1/Th2细胞因子水平变化及临床意义
- Author:
Yuanyuan LIU
;
Zhenhua MA
;
Rongli PIAO
;
Junqi NIU
- Publication Type:Journal Article
- Keywords:
thymosin;
hepatitis B;
cytokines
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of Th1/Th2 cytokines levels in serum in patients with chronic hepatitis B patients befroe and after treatment of thymosin,and clarify the relationship with state of illness,curative effect and virological response.Methods 19 patients with chronic active hepatitis B were chosen as treatment group,10 cases as normal control group.The patients in treatment group were treated with injection of thymosin ? 1 mL,in the pre-treatment,13 and 21 weeks after treatment the cytokine levels,HBV DNA,and biochemical indicators of liver function were detected by flow cytomertry on Tuesday,Friday every week;in normal control group the serum IL-2,IFN,TNF,IL-4,IL-6,IL-10 indicators were determined and the relationship between cytokine levels and biochemical responses and virological response was analyzed.Results After thymosin treatment,the cytokine levels secreted by Th cells were increased compared with pre-treatment (P
