Expressions of progesterone receptor A and B in breast cancer and adjacent non-malignant tissues and significances
- VernacularTitle:孕激素受体A、B在乳腺癌和癌旁乳腺组织中的表达及其意义
- Author:
Bing HAN
;
Sijie LI
;
Tong FU
;
Zhimin FAN
;
Dong SONG
- Publication Type:Journal Article
- Keywords:
progesterone receptor;
breast neoplasms;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of progesterone receptor A (PRA) and B (PRB) in breast cancer and adjacent non-malignant tissues and the correlations between their expressions and the clinical characteristics. Methods The expressions of PRA and PRB in 50 specimens of female human breast cancer and adjacent non-malignant tissues were detected by immunohistochemistry. The correlations between the expressions of PRA and PRB and the clinical characteristics were analyzed.Results PRA and PRB expressed in both the nuclei and the cytoplasma of tumor cells and epithelial cells of the acini and ducts.The percentages of PRA and PRB positive cells were 42%,42% and 52%,36% in the cancer and the adjacent non-malignant tissues,respectively,there was no significant difference.The expression of PRA was significantly correlated with the age of patient(r=-0.316 8,P
