Effect of polyi:c on angiogenesis in mouse prostate carcinoma tissue
- VernacularTitle:聚肌胞对小鼠前列腺癌组织内血管生成的影响
- Author:
Yuantong TIAN
;
Yi ZHONG
;
Jing ZENG
;
Xuejian ZHAO
;
Lijuan ZHAO
- Publication Type:Journal Article
- Keywords:
polvriboinsine-polyribocyaidylic acid;
prostaic neoplasms;
vascular endothelial growth factor;
endothelial nitric-oxide synthase
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of polyi:c on angiogenesis in mouse prostate carcinoma tissue and their possible mechanisms.Methods Mouse prostate carcinoma models were randomly divided into two groups according to tumor weight:control group and polyi:c group.After treatment for 7 times,the mice were sacrificed and the tumor tissues were cut for weighing,calculating the tumor inhibitory rate and tumor index.Hematoxylin-eosin staining and immunohistochemical staining were performed to observate the morphological changes of prostate carcinoma tissues,distribution of vasa and expressions of vascular endothelial growth factor (VEGF) and endothelial nitric-oxide synthase (eNOS).Results In polyi:c group,the mean tumor inhibitory rate was 67.85% and the tumor index was(5.42?0.17)%;in control group,the tumor index was(14.45?1.06)%; there was significant differences between polyi:c group and control group( P
