Cancer therapeutic vaccines targeting hTERT-derived T-cell epitope peptide: Advances in researches
- VernacularTitle:靶向人端粒酶逆转录酶T细胞表位肽的治疗性癌症疫苗研究进展
- Author:
Jian GENG
;
Longbang CHEN
- Publication Type:Journal Article
- Keywords:
Cancer vaccine;
hTERT;
T-cell epitope
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Human telomerase reverse transcriptase(hTERT),a catalytic subunit of telomerase,is highly expressed in a vast majority of cancer cells,but not in most normal adult cells,which makes it a broadly applicable molecular target for cancer immunotherapy.T cell epitope-based vaccines make use of T-cell epitopes from tumor antigens,and have its own unique advantages in cancer immunotherapy.The T-cell epitope peptide vaccine derived from hTERT can efficiently evoke specific cytotoxic T lymphocytes(CTL) responses,and has exhibited its anti-tumor effect in vivo in mice.Now it has already been put into experiment on human beings and displayed a good application prospect.
